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The molecular fragment on an antigen molecule that a lymphocyte recognizes and responds to is called a/ an


A) epitope.
B) hapten.
C) antigen binding site.
D) variable region.

E) B) and C)
F) A) and C)

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Killed or inactivated vaccines are prepared by


A) removal of virulence genes from the microbe.
B) treatment with formalin, heat, or radiation.
C) passage of the pathogen through unnatural hosts or tissue culture.
D) long-term subculturing of the microbe.
E) All of these choices are correct.

F) B) and D)
G) B) and E)

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Gamma globulin can be given as immunotherapy to confer artificial passive immunity.

A) True
B) False

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Vaccinia virus is often used in the technique to make


A) adjuvant.
B) booster.
C) antibodies to toxin.
D) gamma globulin.
E) "Trojan horse" recombinant vaccine.

F) B) and D)
G) C) and D)

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The differences in the classes of immunoglobulins are due primarily to variations in the Fc fragment.

A) True
B) False

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Sam works in construction and stepped on a sharp nail. He can't remember the last time he had a tetanus shot. What type of immunity is the most important for him to receive?


A) natural active immunity
B) artificial passive immunity
C) natural passive immunity
D) artificial active immunity

E) B) and C)
F) B) and D)

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Cody is 4 months old and is given a DTaP injection by his pediatrician as part of the routine immunization schedule. What type of immunity will develop as a result of this?


A) natural active immunity
B) artificial passive immunity
C) natural passive immunity
D) artificial active immunity

E) B) and C)
F) C) and D)

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All of the following are advantages of attenuated vaccines over inactivated vaccines except


A) they require smaller doses.
B) they require fewer boosters.
C) they confer longer lasting protection.
D) they can be transmitted to other people.
E) they produce infection but not disease.

F) A) and B)
G) B) and C)

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Which process involves a more rapid synthesis and greatly increased titer of antibody when the immune system is subsequently exposed to the same antigen?


A) neutralization
B) opsonization
C) complement fixation
D) agglutination
E) anamnestic response

F) A) and B)
G) B) and D)

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Edward Jenner's work involved


A) inoculation of dried pus from smallpox pustules into a person to stimulate immunity.
B) development of passive immunotherapy.
C) development of an immunization to protect people against cowpox.
D) immunization using a related, less pathogenic organism to give protection against a more pathogenic one.
E) All of these choices are correct.

F) B) and E)
G) B) and C)

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The immunoglobulin class that has a dimer form found in mucus, saliva, colostrum, and other body secretions is


A) IgA.
B) IgD.
C) IgE.
D) IgG.
E) IgM.

F) B) and D)
G) D) and E)

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Cell surface markers involved in immune reactions


A) are the result of genetic expression.
B) function in recognition of self molecules.
C) participate in communication with other cells of the system.
D) aid in cellular development.
E) All of these choices are correct.

F) D) and E)
G) A) and B)

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Lymphocytes


A) possess MHC antigens for recognizing self.
B) have membrane receptors that recognize foreign antigens.
C) gain tolerance to self by destruction of lymphocytes that could react against self.
D) develop into clones of B and T-cells with extreme variations of specificity.
E) All of these choices are correct.

F) A) and C)
G) C) and D)

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Superantigens are


A) body tissues that the immune system mistakes as foreign.
B) cell markers found in some member of a species but not in other members.
C) bacterial toxins that activate T-cells at a 100 times greater rate than other antigens.
D) those that evoke allergic reactions.

E) A) and D)
F) None of the above

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Which sequence of events is correct for a specific immune response?


A) lymphocyte development, presentation of antigens, antibody production, challenge of B-cells
B) lymphocyte development, challenge of B-cells, antibody production, presentation of antigens
C) lymphocyte development, presentation of antigens, B-cell challenge, antibody production
D) antibody production, lymphocyte production, B-cell challenge, presentation of antigens
E) presentation of antigens, B-cell challenge, antibody production, lymphocyte development

F) A) and E)
G) A) and B)

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The monomer subunit of immunoglobulin molecules has all the following, except


A) two identical heavy polypeptide chains.
B) two identical light polypeptide chains.
C) disulfide bonds between polypeptide chains.
D) four antigen binding sites.
E) a variable and constant region on each polypeptide chain.

F) C) and D)
G) B) and E)

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Antibody molecules can act as enzyme to directly destroy an antigen.

A) True
B) False

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